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Co-labelling for the motor neuron marker choline acetyl-transferase and for SMN revealed that at 1 month of age, an age prior to development of pathology or abnormal motor phenotypes, expression of mutant R521C had already provoked a slight reduction of Gems (Fig

This can result in complications such as cardiac hemosiderosis (leading to heart failure), hepatic fibrosis and cirrhosis, diabetes mellitus (due to pancreatic iron deposition), and hypogonadotropic hypogonadism causing delayed or absent puberty

[DOI] [PubMed] [Google Scholar] 172.Marino G, Kroemer G

Is it normal for symptoms to initially worsen before improving with B12 therapy
Kerman et al., 2012
