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The PI(3)P hypothesis originated from research on oomycetes, where virulence effectors containing an RxLR motif are directed into plant host cells by binding to PI(3)P on the cell surface followed by endocytosis 39,56 , although this has now been challenged (reviewed in ref

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This may be related in part to dose-related preferential recruitment of receptor subtype, since the adenosine A 1 receptor exhibits many opposing physiological functions to those mediated by the A 2A receptor, including stimulation of neutrophil adherence to endothelial cells

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[DOI] [PubMed] [Google Scholar] Miao Y., Lv D., Wang P., Wang X.C., Chen J., Miao C
doi: 10.1074/jbc.M009814200
