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S -(2 , 3 - O -Isopropylidene-uridine-5 -yl)-dithioacetic acid (21): Method A : CS 2 (91 L, mmol, 3.0 equiv.) was dissolved in dry THF (4 mL) under Ar and MeMgBr 3 M solution in diethyl ether (0.5 mL, 1.5 mmol, 3.0 equiv.) was added and stirred overnight

B.IversenM.HibyN.et al

While in one meta-analysis liver ultrasound was found to have a pooled sensitivity of 84.8% and specificity of 93.6% to detect hepatic steatosis of more than 20-30% (119), this literature is largely from liver clinics where disease severity is greater (i.e., more steatosis and better performance) but may not reflect the setting of primary care physicians or endocrinologists

Results Identification of C1-27 as a potent GSTO1 inhibitor The -chloroacetamide is a privileged scaffold that has been commonly used to target cysteine residues on various proteins 20,21,25

AAV-EGFP served as the vector control in this study

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