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Nishikawa M, Kakemizu N, Ito T, Kudo M, Kaneko T, Suzuki M, Udaka N, Ikeda H, Okubo T (1999) Superoxide mediates cigarette smoke-induced infiltration of neutrophils into the airways through nuclear factor-kappaB activation and IL-8 mRNA expression in guinea pigs in vivo

SARS-CoV-2 can also infiltrate the CNS by affecting the BBB, e.g., infecting endothelial cells to go through the BBB or triggering inflammatory response to damage BBB (Tana et al., 2022)

S246801412500055X Zeman MK, Lin JR, Freire R, Cimprich KA (2014) DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis

In multi-week studies, a small percentage of subjects did develop low-titer, non-neutralizing antibodies to CJC-1295

Ferritin (iron storage protein) and transferrin receptor (iron uptake protein) further influence neuronal iron homeostasis, which is often dysregulated in conditions such as AD and PD (Levi et al., 2024)

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