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It was reported that curcumin administration at 100 mg/kg body weight/day for 1421 days significantly improved spatial memory, reduced lipid peroxidation, and restored the activities of key antioxidant enzymes, including SOD, CAT, and GPx, in rat models of homocysteine induced neurotoxicity (Ataie et al

10.1016/S1470-2045(18)30608-9 34 ShiravandY.KhodadadiF.KashaniS

10.1165/ajrcmb/9.6.628 62 KasperM.HaroskeG

In moderate amounts its harmless, but in combination with high caffeine doses it can alter testicular enzyme activity and interfere with sperm maturation

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