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However, zincs significance in normal cellular functions, including DNA repair 610 and immune responses, 611 warrants caution to minimize off-target toxic effects

Interestingly, two possible gain of functions mechanisms are thought to be induced by the C9orf72 repeat expansion

This prolonged intracellular environment differentiates it from shorter-acting IGF variants

Cytokines and chemokines

On the other hand, impaired mitophagy is linked to many positive and negative processes, such as development, aging, cardiovascular diseases and cancer

Body_ID: PB35017 The consumption of O 2 by NADPH oxidase is responsible for the 'respiratory burst', the sharp increase in O 2 consumption for production of ROS, which accompanies phagocytosis