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The placenta exposes maternal melatonin to the fetus at daily rhythmic intervals, with low concentrations during the day and high concentrations at night ( in utero and in adult life (56, 61, 73)

doi: 10.1128/IAI.71.6.3034-3042.2003

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Goal-Specific Dosing Considerations The optimal MOTS-c dose is not one-size-fits-all: it shifts depending on whether the clinical goal is metabolic correction, athletic performance enhancement, or anti-aging and longevity support

[Abstract] J Biol Chem

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