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These agents ameliorate skin lesions without altering joint inflammation, consistent with clinical experience that anti-IL-17 or anti-TNF therapies often yield better cutaneous than articular responses

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Spider angioma, involving central arterioles surrounded by radiating capillaries, occurs in 33% of alcohol-associated cirrhosis cases and is also linked to hepatopulmonary syndrome, arising from increased blood flow to the surface capillaries

[DOI] [PMC free article] [PubMed] [Google Scholar] 28.Feng H., Schorpp K., Jin J., Yozwiak C.E., Hoffstrom B.G., Decker A.M., Rajbhandari P., Stokes M.E., Bender H.G., Csuka J.M., et al

In cigarettes, nicotine has been identified as the component primarily responsible for the vascular consequences resulting from persistent smoking [145]