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The ,-unsaturated enone moiety of resorcylic acid lactones is susceptible to Michael addition reaction with a conserved cysteine residue (Cys166 in human ERK2) (95)

Mitochondria-derived methylmalonic acid aggravates ischemia-reperfusion injury by activating reactive oxygen species-dependent ferroptosis

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Igf/Shh interaction is reported to occur on various levels

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