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A Chinese cohort study reported that high-alcohol-producing Klebsiella Pneumoniae (HiAlc-Kpn), which produces large amounts of alcohol, was detected in 61% of MASLD patients

Its ability to inhibit key drug efflux pumps, modulate resistance-related signaling pathways, and restore the effectiveness of standard chemotherapies highlights its potential as an adjuvant in cancer therapy

Endosomal pathways initiate autophagosomes and exosome formation and remove damaged organelles, including oxidative stress-generating mitochondria that promote inflammation and connective tissue remodelling

10.1016/0041-008x(91)90091-r [DOI] [PubMed] [Google Scholar] Wang X., Wu W., Zheng W., Fang X., Chen L., Rink L., et al

Any safety discussion should therefore include downstream GH/IGF-1 effects as relevant endpoints

Acknowledgements Research in the laboratory of VMM is supported by National Institute for Health Research (NIHR) Biomedical Research Centre, Cancer Research UK Oxford Cancer Research Centre, Breast Cancer Now, The Rosetrees Trust and UCARE-Oxford
