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As predicted, mutations in daf-36 , a key oxygenase converting cholesterol to 7-dehydrocholesterol (55), dramatically increased droplet size, whereas mutations in mboa-1 , the homolog of mammalian acyl-coenzyme A: cholesterol acyltransferases (ACATs) catalyzing the cholesterol esterification (56), decreased droplet size (Fig 3A and B)

The pathological process is called oxidative stress, which is also one of the main mechanisms of damage caused by high-altitude, low-pressure and low-oxygen environmental factors

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elegans ) is a versatile and widely used animal model for in vivo studies of a broad range of human diseases, in particular for understanding their genetic origins and for screening drug candidates

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October 2011