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The energy of the resulting structure was minimized utilizing AMBER14:EHT forcefield in MOE 72,73 with all the settings set default until the RMS gradient reached 0.001 kcal/mol/ 2

Hereafter, it translocates to the nucleus where it may induce expression of its many target genes, aligning with the ARE in the promoter region of these genes

Campbell, S

H., Vaishnav Y., Stillwell W

While each offers impressive benefits on its own, their combined effects create a synergistic approach to achieving radiant, youthful skin that goes far beyond what either compound can accomplish alone

In contrast, under stress conditions, ATF4 enhances SLC7 A11 transcription by binding to the amino acid response element (AARE) in the promoter region of SLC7 A11 [22]