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Discovery of novel 20S proteasome subunit 5 PROTAC degraders as potential therapeutics for pharyngeal carcinoma and Bortezomib-resistant multiple myeloma

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Donohue syndrome (also referred to as Leprachaunism), represents the most severe form of this family of disorders, most children die before the age of 2 Rabson-Mendenhall syndrome, symptoms appear in early childhood, most patients die in their teens or early twenties Type A insulin resistance syndrome is a rare disorder of severe insulin resistance, symptoms usually do not appear until puberty or later 6

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Then, 50 (162.7 M) and 100 mg kg 1 (325.4 M) of foliar GSH treatments and 2-ml L 1 of a commercial surfactant (20% sodium lignosulfonate and 10% polyoxyethylene alkyl aryl ether) were simultaneously applied (Jung et al., Based on the results of a previous study by Jung et al