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The intervention on this genetic condition generally required a high dosage, ranging from 5 to 50 mg/kg/day, of oral CoQ 10 supplementation to achieve favorable responses [70]

This ternary complex slows even higher clearance, such that in adult humans, the total IGF-1 concentration in the circulation is around 100 nM

However, the exact molecular mechanisms responsible for this preserved effect remains unclear

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[DOI] [PMC free article] [PubMed] [Google Scholar] 85.Chen, L

Once reconstituted, the solution is refrigerated never frozen