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However, the lack of peroxisomal catalase seems to have impaired the ctl-2(ua90)II mutants ability to properly respond to heat stress, evidenced by lack of lifespan extension, decreased thermotolerance, and a range of metabolic changes when compared with WT worms, which are not confined to peroxisomes

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A classification scheme based on the molecular etiology and pathophysiology of the lipoprotein disorders complements this system and forms the basis for this chapter

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