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A randomized two way cross over study for comparison of absorption of vitamin D3 buccal spray and soft gelatin capsule formulation in healthy subjects and in patients with intestinal malabsorption

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While not every user becomes deficient, the risk is substantial enough to warrant proactive supplementation, particularly during aggressive weight loss phases

NNMT (nicotinamide N-methyltransferase) is an enzyme found in fat cells and other tissues that can become overactive in certain metabolic conditions

Nearly half of the bacteria comprising the human gut microbiome are unable to produce NAD + de novo and rely on NAD + precursors available in the environment for their metabolic functions 59,60