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There is only one FDA-approved (Scenesse), which is only for increasing pain-free light exposure in adults with a serious sun sensitivity

Deficiency causes megaloblastic anemia fewer, larger, less efficient red blood cells that carry less oxygen per cell

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However, a later study found MORs specifically inhibit midline thalamus inputs to layers 2/3 and layer 5 anterior cingulate cortex pyramidal neurons and parvalbumin (PV)-expressing interneurons