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During the adaptation phase, these systems are adjusting

Probiotic treatment prevented MIA-induced increases in IL-6/IL-17a, preserved parvalbumin positive interneurons, normalized GABAergic signaling, and fully rescued social, repetitive, anxiety-and depression-like behaviors in adult offspring (Wang et al., 2019)

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Since nicotinamide boosting could increase the production of oxyradicals from the ETC, we treated the hippocampal neurons with EGCG to control an oxidative redox state that causes ROS overproduction