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Even successful CAR T-cell therapy may fail to reverse established organ damage in autoimmune diseases, as demonstrated by SLE-related glomerulosclerosis, pulmonary fibrosis in systemic sclerosis, exocrine gland fibrosis in Sjgrens syndrome, and demyelinating lesions in multiple sclerosis

Ou Z., Pan J., Tang S., et al., Global Trends in the Incidence, Prevalence, and Years Lived with Disability of Parkinson's Disease in 204 Countries/Territories from 1990 to 2019, Front Public Health 9 (2021): 776847

These factors support neuronal survival, promote synaptic plasticity, and enhance cognitive function

Fakouri NB, Hou Y, Demarest TG, et al

[PubMed] [Google Scholar] 3.Chick, H

doi: 10.3390/stresses2030019