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Since GLP-1 receptor agonists commonly cause nausea, vomiting, diarrhea, and constipationparticularly during dose titrationchoosing a magnesium formulation that doesn't worsen these symptoms is clinically important

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Some feel it almost immediately

CVOT trial will help determine if tirzepatide can demonstrate superior cardiovascular safety and potential additional cardiovascular benefits compared to the currently approved GLP-1RA dulaglutide

This confirms and quantifies the metabolic benefit over the cycle

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