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Nonetheless, also informative, is the observation that studies, albeit far fewer in number, report a lack of efficacy in some models: E.g., tumor xenografts or chemical carcinogenesis, bacterial infections, airways inflammation and cerebral ischemia

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For instance, while REW-containing IgG2 is equipped with the capacity to mediate induction of classical complement activation, IgG4 REW remains inert in this regard, which is a differentiator compared to other reported Fc-engineered strategies

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