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Orally administrated diabetic (intraperitoneal injection of streptozotocin 60 mg/kg) and control Wistar rats were supplemented with vitamin E (0.2, 0.4, 0.8 mg/kg for 3 weeks)

Formigari A, Gregianin E, Irato P

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Its pathogenesis involves tumor-like proliferation of synovial fibroblasts (FLS), local infiltration of immune cells, and the release of inflammatory cytokines that exacerbate joint inflammation and bone destruction ( Ferroptosis is a mode of iron-dependent cell death that is morphologically and biochemically distinct from apoptosis, necrosis, and pyroptosis ( The endoplasmic reticulum (ER), an important organelle in eukaryotic cells, is involved in protein synthesis, folding, structural maturation, lipid metabolism, and Ca 2+ regulation

Pang Z, Chong J, Zhou G, de Lima Morais DA, Chang L, Barrette M