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2 The use of pharmacologic agents has been controversial in the past owing to inconsistent efficacy and the high rate of spontaneous recovery
The process typically works as follows
10.3748/wjg.v22.i41.9127 [DOI] [PMC free article] [PubMed] [Google Scholar] Drmic D., Kolenc D., Ilic S., Bauk L., Sever M., Sever Z., et al
Studies in aged animal models have shown that NAD+ precursor supplementation can improve endothelial function as measured by flow-mediated dilation and arterial stiffness parameters in research animals
As such, secondary outcomes include changes in cognition, disease severity and function before and after treatment and across the one-year study period and measures of senescence and AD biomarkers in CSF pre- and post-treatment (baseline and three months) with an optional end of study collection
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