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This review uses the diagnostic criteria of the ECNM-AIM consortium and provides a practical roadmap, specifically tailored for Canadian allergists, to diagnose and manage MCAS while assessing for the co-existence of a clonal mast cell disorder (CMCD) and ruling out key secondary causes of mast cell activation (MCA)

J Biol Chem 251 : 42874293 Pisoni RL, Acker TL, Lisowski KM, Lemons RM, Thoene JG 1990 A cysteine-specific lysosomal transport system provides a major route for the delivery of thiol to human fibroblast lysosomes: possible role in supporting lysosomal proteolysis