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Established pulmonary hypertension in rats was reversed by a combination of a HIF-2alpha antagonist and a p53 agonist

However, in a hypoxic environment, vascular endothelial growth factor and HIF-1 are activated in tumor cells, increasing tumor neovascularization and the likelihood of metastasis

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Forty-two male rats were split into six groups: control, doxorubicin + exercise, doxorubicin + garlic, saline, doxorubicin, and doxorubicin