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Limitations: Narrative review rather than systematic review with meta-analysis

Limitations and Challenges Related to the Use of Peptides Incorporated in Wound Dressings Despite their promising therapeutic potential, peptide-based wound dressings face a number of scientific, technical, regulatory, and clinical limitations that hinder their widespread adoption in clinical practice

In the ATTAIN-2 trial (participants with obesity and type 2 diabetes), GI adverse event rates were somewhat higher than in ATTAIN-1: nausea 20.1-36.4% versus 8.4% with placebo, vomiting 12.8-23.1% versus 3.8%, diarrhea 21.3-27.4% versus 15.0%, and constipation 17.7-22.4% versus 7.8%

And the results are the evidence

Low: P = 0.011

We recommend starting with the same daily schedule for three months, until symptoms stop improving, and then starting to test