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N Engl J Med 371:313325 Gough SC, Bode B, Woo V et al (2014) Efficacy and safety of a fixed-ratio combination of insulin degludec and liraglutide (IDegLira) compared with its components given alone: results of a phase 3, open-label, randomised, 26-week, treat-to-target trial in insulin-naive patients with type 2 diabetes

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Insulin binding causes autophosphorylation of its receptor, resulting in activation and subsequent tyrosine phosphorylation of insulin receptor substrates and binding of the p85 regulatory subunit of phosphatidyl inositol kinase-3 (PI3K)

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