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For example, one rat study found that an abundance of hydrogen sulfide-producing species (e.g., Fusobacterium and Desulfovibrio ) in the gut contributed to diarrhea-predominant irritable bowel syndrome

This pathway triggers the suppression of self-renewal and cell differentiation

NSCs typically rely heavily on the glycolytic pathway to meet their energetic demands ( Similar to normal stem cells, cancer stem cells (CSCs) also exhibit a strong glycolytic phenotype, which enables them to survive in the hostile, hypoxic regions of the tumor microenvironment (TME) and drive tumorigenesis ( 3.2 Cancer stem cells: a plastic state governed by the microenvironment CSCs represent a subpopulation within tumors that are widely regarded as the principal cellular drivers of tumor initiation, therapeutic resistance, relapse, and metastatic spread