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Excess inflammatory signaling continues to degrade tissue or disrupt healing
Exercise and sleep deprivation do not change cytokine expression levels in patients with chronic fatigue syndrome

Some individuals experience mild gastrointestinal effects including nausea or abdominal discomfort, particularly with higher doses or when first initiating therapy
In fact, in skeletal muscle fibroblasts, oxidant-induced upregulation of GPx-1 expression was transcriptionally mediated by activation of NFB (410)
10.1084/jem.20190257 J

doi: 10.1111/j.1753-4887.1990.tb02967.x