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From glucose to lactate and transiting intermediates through mitochondria, bypassing pyruvate kinase: Considerations for cells exhibiting dimeric pkm2 or otherwise inhibited kinase activity

One key concern is the long-term impact of glutathione supplementation or treatment on skin health, particularly the risk of skin cancer

Toxicol Sci 180(2):369382

SARS-CoV-2 ORF6 protein has also been shown to dysregulate redox homeostasis by decreasing Nrf2 expression, which can enhance viral replication 69

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