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Methods For the induction of DN single intraperitoneal administration of STZ (45 mg/kg) was given till third week

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The hepatic histological lesions in EAFMP were reduced in a dose-dependent manner

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Importantly, 4-HNE-tubulin adduction, as well as increased aneuploidy rates, were resolved by co-treatment with the antioxidant penicillamine, demonstrating a possible therapeutic mechanism to improve oocyte quality in older females.