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Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury

The same targeting mechanism allowed for selective delivery of ferroptosis inhibitors to the affected coronary territory, demonstrating superior cardioprotection compared to systemic therapy in experimental coronary occlusion models

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Another preclinical study using presymptomatic and symptomatic SOD1 G93A transgenic mice revealed an association between the accumulation of ceramides and cholesterol esters in the spinal cords of ALS patients and OS, thus highlighting the pivotal role of OS in inducing an alteration in the metabolism of sphingolipids metabolism which mediates MN death in ALS [112]