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IR leads to hepatic lipid metabolism disorders, particularly affecting fatty acid -oxidation, DNL and VLDL synthesis [73]

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Hyperhomocysteinemia and elevated MMA can also arise from Imerslund-Grsbeck syndromea rare autosomal recessive disorder caused by mutations in either the CUBN or AMN gene responsible for the synthesis of IF receptors (cubam) in the ileum (distal region of the small intestine) (35)

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Protein bands of interest were reduced and alkylated using dithiothreitol and iodoacetamide, respectively

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2012 Feb 17;203:194206

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