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In vivo , DK-3 treatment reduced tau phosphorylation (Thr181, Thr205, Ser396) and inflammation markers such as IL-6, CoX-2, and IL-1, alleviating neuronal damage (Ji et al., 2021)

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Moreover, knockout (KO) mice lacking the antioxidant transcription factor Nrf2 displayed depression-like behaviors in various tests (Dang et al., 2022

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Table 3 Representative preclinical doses and illustrative human-equivalent dose (HED) anchors for key MFH actives

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