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In a research setting, this is often done to minimize the number of injections

doi: 10.1039/C6NP00074F
However, with exposure to larger quantities, there may be sufficient cooling to produce a lesion similar to frost-bite (Hine & Rowe, 1981)

Immunofluorescence assay confirmed the colocalization of NK1R and STING in Caco-2 cells (Figure 8B, C), suggesting that SP might directly modulate the STING pathway

ELWI, Extravascular lung water index

The prevalence and burden of primary headaches in China: A population-based door-to-door survey
