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This led to the discovery of the short gene regulatory regions called antioxidant response elements (AREs) that are required for xenobiotic and oxidative stress-induced expression of phase II detoxification enzymes (Rushmore and Pickett, 1990

(PubMed) Zhai J, Bo Y, Lu Y, Liu C, Zhang L

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Codelivery strategies, such as combining siRNA with GM to enhance endosomal escape, have further improved gene silencing efficacy in cancer models

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