liver glutathione reductase Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and The Selenoprotein Glutathione Peroxidase 4:

Blood (2019) 134(Supplement_1):1385

Calverley, P

Similarities Between Glutathione and Glutathione Peroxidase Both glutathione and glutathione peroxidase serve as essential components of the antioxidant defense system in the body

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Alkaline pH, exposure to light and heat, and the presence of oxygen, water, or some metals (Cu, Fe) causes the oxidation of ascorbic acid through the dehydrogenation of the two hydroxyl groups at C 2 and C 3 , with the formation of DHA [73]

It follows that UCP2 gene variants associated with lower UCP2 protein levels, and therefore less protection against ROS and oxidative stress, could also be linked to these cardiometabolic diseases