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Mitochondrial dysfunction has been addressed in several open-label, non-placebo-controlled trials, which indicated that treatment with idebenone might ameliorate hypertrophic cardiomyopathy

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doi: 10.1038/s41598-017-11744-6 94

Moreover, MYC, increases mitochondrial export of acetyl groups as the form of citrate and the resulting acetyl-CoA contributes to histone acetylation by histone acetyltransferase GCN5 (117)

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