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The absence of a specific trial doesn't negate the overwhelming body of indirect and mechanistic evidence

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J Agriculture Food Research

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J Agric Food Chem 49(7):31783186 [DOI] [PubMed] [Google Scholar] Hernandez-Damian J, Anderica-Romero AC, Pedraza-Chaverri J (2014) Paradoxical cellular effects and biological role of themultifaceted compound nordihydroguaiaretic acid

Then HMG-CoA reductase (HMGCR) reduces HMG-CoA to MVA via an irreversible reaction