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Aggressive exercise regimens often worsen symptoms, but maintaining tolerable activities is important to prevent worsening the condition

Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases

Hawley 2015)
Acta 77 MagoulasP

Another interesting class of hypoglycemic drugs with positive kidney outcomes are the SGLT2 inhibitors (SGLT2i) which inhibit glucose and sodium reabsorption in the PT (Perkovic et al., 2019) independently of glycemic control (Williams et al., 2020)

Npj Microgravity