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Description
The cavity is completely occluded from the cytosol with only one opening on the side of the 7-TM domain between TM1 and TM4
Nat Rev Genet (2009) 10:295304
10.1186/s12967-023-04179-3 63 GkouviA.TsiogkasS
Its primary research significance lies in its capacity to activate the enzyme telomerase (specifically the catalytic subunit hTERT) and modulate chromatin structure
& Kelly, E
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