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AugustinKWilliamsSCunninghamMDevlinAMFriedrichMJayasekeraAet al

doi: 10.1016/j.ajog.2021.08.012 91

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Network/pathway association To get an impression of which biological processes and pathways are overrepresented in these networks (as well as the entire mutation/CNV dataset), we performed GO enrichment (using the R package topGO ( and pathway enrichment (hypergeometric tests using the Molecular Signature Databases (MSigDb v.5.1) C2 gene sets for Canonical Pathways, Biocarta, Reactome and KEGG), followed by FDR adjustment of P values (using Rs p.adjust function)

These findings suggest IDH1 plays a significant role promoting fatty acid synthesis and lipid metabolism in cancer