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There are anecdotal reports of adverse effects such as injection site pain, anxiety, insomnia, headaches, dizziness, and gastrointestinal discomfort, but these are not well-documented in clinical studies

In a case series of patients with treatment-resistant depression, pramipexole (D3 agonist) treatment was particularly effective in patients with higher levels of IL-17 (Fawcett et al., 2016)

Brief room-temperature exposure during normal handling is usually unavoidable

Sleep deprivation and chronic stress elevate ghrelin (the hunger hormone) and blunt GLP-1 signaling, creating resistance to the medication's benefits

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[DOI] [PubMed] [Google Scholar] 119.Atarashi K, et al
