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B12 supplementation has also been shown to promote DNA methylation changes and affect the antidepressant response in a mouse model [161]

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What It Is Class: Non-peptide GH secretagogue / ghrelin-receptor agonist Target: Growth hormone secretagogue receptor (GHS-R1a), related to endogenous ghrelin Research focus: GH/IGF-1 axis, body composition, appetite, and metabolic endpoints Proposed Mechanisms (Preclinical) Ghrelin Receptor & GH/IGF-1 Axis Acts as an agonist at GHS-R1a , mimicking ghrelin at pituitary and hypothalamic sites

We considered studies testing hyperbaric or normobaric hyperoxicnormoxic stimulus in adult healthy subjects and studies which evaluated potential oxygen effects on adult patients scheduled for general or cardiac surgery

doi:10.1007/s00726-011-0867-5 16