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Front Immunol 9:2616 Quach H, Benson S, Haysom H, Wilkes A, Zacher N, Cole-Sinclair M et al (2018) Considerations for pre-transfusion immunohaematology testing in patients receiving the anti-CD38 monoclonal antibody daratumumab for the treatment of multiple myeloma

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46 Importantly, the majority of the CD38 enzyme exists as a Type II membrane protein with its catalytic site facing the outside of the cell, thus CD38 is mainly an ectoNAD glycohydrolase

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