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In the light of excellent performance of BBB crossing strategies for enhanced drug delivery, we will first summarize the structure and different cells contributing to the integrity of BBB (Fig

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iv) morphological plasticityfrom spiral to coccoid-shape as a defense against adverse conditions and v) biofilmsthat shield the bacterium from antimicrobial agents, increasing treatment failure and infection recrudescence [12, 13]

After carefully reviewing and screening, 23 articles [3, 728] were finally included in the meta-analysis

doi: 10.1074/jbc.RA120.014266 32 McCoyA

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