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The first cardiovascular study of NNMT enzyme inhibition in a heart failure with preserved ejection fraction (HFpEF) mouse model demonstrated that treatment markedly reduced 1-MNA (by 77.1%), 2PY (by 66.2%), and 4PY (by 71.1%) in cardiac tissue, while improving cardiac function, enhancing global longitudinal strain, reversing peak longitudinal strain rate, and significantly reducing left ventricular hypertrophy and fibrosis

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While animal studies have suggested numerous potential benefits of BPC-157, there is still a lack of clarity regarding its effects, side effects, and appropriate dosing in clinical settings

In a study using rats with diet-induced obesity, tesofensine was found to significantly reduce body weight by suppressing appetite

doi: 10.3390/ijms160922555

That information, combined with a discussion of your treatment goals, helps him determine the right approach for your needs