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1991Int Orthop

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Ongoing clinical trials are evaluating other ASO candidates targeting genes such as C9orf72 (e.g., WVE-004, NCT04931862) and FUS (e.g., ION363, NCT04768972), as well as ASOs for other targets like ATXN2 (BIIB105, NCT04494256) and SOD1 (e.g., ISIS SOD1Rx, NCT01041222) (8, 15, 16)

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Ability of Lactobacillus to tolerate acid and bile The isolated strains were incubated at different pH (2, 3, 4, 5, 6) or bile salt (0.1%, 0.2%, 0.3%, 0.4%, 0.5%) for 16 h at 37Cfor 16 h

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doi: 10.3389/fphar.2024.1407659

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Br J Pharmacol 149:967978 Acknowledgements This review was supported by So Paulo State Foundation for the Support of Research (FAPESP, Brazil

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Method Selection criteria We searched research articles exclusively published in peer-reviewed journals

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