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Ongoing clinical trials are evaluating other ASO candidates targeting genes such as C9orf72 (e.g., WVE-004, NCT04931862) and FUS (e.g., ION363, NCT04768972), as well as ASOs for other targets like ATXN2 (BIIB105, NCT04494256) and SOD1 (e.g., ISIS SOD1Rx, NCT01041222) (8, 15, 16)

Ability of Lactobacillus to tolerate acid and bile The isolated strains were incubated at different pH (2, 3, 4, 5, 6) or bile salt (0.1%, 0.2%, 0.3%, 0.4%, 0.5%) for 16 h at 37Cfor 16 h
doi: 10.3389/fphar.2024.1407659

Br J Pharmacol 149:967978 Acknowledgements This review was supported by So Paulo State Foundation for the Support of Research (FAPESP, Brazil

Method Selection criteria We searched research articles exclusively published in peer-reviewed journals
