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A 2008 study published in the Journal of Medicinal Chemistry demonstrated metabolic effects in rodent models at 50mg/kg, which led early researchers to extrapolate human-equivalent doses between 50100mg daily

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[DOI] [PMC free article] [PubMed] [Google Scholar] 266.Shivananda Nayak B, Duncan H, Lalloo S, Maraj K, Matmungal V, Matthews F, Prajapati B, Samuel R, and Sylvester P