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PPM1D phosphatase, a target of p53 and RBM38 RNA-binding protein, inhibits p53 mRNA translation via dephosphorylation of RBM38

The vast majority of IGF-1 is secreted by the liver (Laron, 2001) with tissues like skeletal muscle also contributing to IGF-1 release during resistance exercise (Perrone et al., 1995)

732 Wnt2 signaling pathway activation further augments glutamine metabolism, thereby underpinning the energetic demands of cancer cell proliferation and metastasis

We applied the MannWhitney U test to data that did not follow a normal distribution

Standard dose escalation schedule Clinical trials established the dose escalation approach that minimizes gastrointestinal side effects while achieving therapeutic levels

We synthesize evidence and propose recommendations for establishing standardized efficacy evaluation systems and advancing mechanistic studies of TMMM